At some point in your animal husbandry journey, you're going to have a dog that needs to undergo a procedure and typically depending on the procedures "invasiveness"; they are probably going to suggest your dog be "put under" for the procedure to be completed.
No need to panic.... Our first recommendation..... ALWAYS do "pre-surgical lab work" this is a two part blood test that gives your veterinarian team VERY IMPORTANT information about your pets health at the moment. A Complete Blood Count (CBC) and a serum blood chemistry. In Short, this pre-surgical lab work makes sure your pet is "well enough" to handle the anesthesia and will indeed wake up after the fact. (We'd say that's pretty important information, don't you think!)
You may want to ask your vet what kind of anesthesia will be used during any procedures, as the older drug Halothane is not considered as safe as Isoflurane and other newer anesthetics.
If you have a dog prone to any type of seizure disorders (My American Bully Line Carries NCL4A (Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia; is the medical name) so we are personally always VERY cautious with anything prescribed or over the counter (Benadryl is a big no in my home). Although Carriers of a disease are not supposed to suffer from the disease, their "threshold is lower"; meaning when introduced to something with "KNOWN" neurological/ seizure side effects; that's an immediate no for us!),
We would highly encourage you to talk to your vet about avoiding the use of Phenothiazine tranquilizers (such as acepromazine) and ketamine.
Certain breeds are "prone" to having problems with certain medication drugs, including breeds like (but not limited to) Belgian Shepherds, Greyhounds and other Sighthounds, Brachycephalic dogs (such as Bulldogs, Pugs and yup... US! American Bullies are considered Brachy breeds), Mastiffs, Boxers and Bull Terriers (Acepromazine),
It will never hurt you or your relationship with your veterinarian to be sure your vet is aware of this before your dog has surgery (or just undergoes any type of anesthesia procedure - ie: Health Testing Clearances (OFA and PennHip).
The Handbook of Veterinary Drugs says "Giant breeds, as well as greyhounds, appear quite sensitive to the clinical effects of the drug [Acepromazine], yet terrier breeds appear more resistant. Boxer dogs, on the other hand, are predisposed to hypotensive and bradycardic effects of the drug."
Acepromazine (Ace) and Butorphanol (Torbutrol, Torbugesic) are among the drugs that most breeds may be the most sensitive to.
The MDR1 mutation causes multidrug sensitivity in some breeds, including Australian Shepherds (standard and miniature), Border Collies, Collies, English Shepherds, German Shepherds, Longhaired Whippets, McNabs, Old English Sheepdogs, Shetland Sheepdogs, Silken Windhounds, and any/all mixed-breed dogs from any of these breeds also. Embark does test for MDR1 although it is NOT a test that is "specific" to our breed, I have yet to see anyone's results from the Health Testing American Bully Community say they have dogs who are considered "carriers" or "affected" of this MDR1 gene; which leads me to believe it is not exactly a bullet proof resource for this result (yet) at this stage in the Health Testing game for our breed.
Here's a really great blog about anesthesia considerations also, if you enjoy reading a bit:
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